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1

Perforin and granzymes: function, dysfunction and human pathology

Voskoboinik, Ilia, Whisstock, James C., Trapani, Joseph A.

Journal:

Nature Reviews Immunology

Year:

2015

Language:

english

File:

PDF, 787 KB

english, 2015

2

Brentuximab vedotin in T-cell lymphoma

van der Weyden, Carrie, Dickinson, Michael, Whisstock, James, Prince, H. Miles

Journal:

Expert Review of Hematology

Year:

2018

Language:

english

File:

PDF, 1.32 MB

english, 2018

3

Protein structural alignments and functional genomics

James A. Irving, James C. Whisstock, Arthur M. Lesk

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2001

Language:

english

File:

PDF, 190 KB

english, 2001

4

Multiple alignment and sorting of peptides derived from phage-displayed random peptide libraries with polyclonal sera allows discrimination of relevant phagotopes

Janet M Davies, Marita Scealy, YePing Cai, James Whisstock, Ian R Mackay, Merrill J Rowley

Journal:

Molecular Immunology

Year:

1999

Language:

english

File:

PDF, 175 KB

english, 1999

5

Prediction of protein function from protein sequence and structure

Whisstock, James C., Lesk, Arthur M.

Journal:

Quarterly Reviews of Biophysics

Year:

2003

Language:

english

File:

PDF, 648 KB

english, 2003

6

New insights into the structure and function of the plasminogen/plasmin system

Law, Ruby HP, Abu-Ssaydeh, Diana, Whisstock, James C

Journal:

Current Opinion in Structural Biology

Year:

2013

Language:

english

File:

PDF, 1.59 MB

english, 2013

7

Brinp1−/−mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Berkowicz, Susan R., Featherby, Travis J., Qu, Zhengdong, Giousoh, Aminah, Borg, Natalie A., Heng, Julian I., Whisstock, James C., Bird, Phillip I.

Journal:

Molecular Autism

Year:

2016

Language:

english

File:

PDF, 3.05 MB

english, 2016

8

Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signalling Pathway in Drosophila

Henstridge, Michelle A., Aulsebrook, Lucinda, Koyama, Takashi, Johnson, Travis K., Whisstock, James C., Tiganis, Tony, Mirth, Christen K., Warr, Coral G.

Journal:

Year:

2018

Language:

english

File:

PDF, 3.02 MB

english, 2018

9

Modeling of serpin-protease complexes: Antithrombin-thrombin, α1-antitrypsin (358Met→Arg)-thrombin, α1-antitrypsin (358Met→Arg)-trypsin, and antitrypsin-elastase

Whisstock, James, Lesk, Arthur M., Carrell, Robin

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1996

Language:

english

File:

PDF, 1.85 MB

english, 1996

10

Serpins in the Caenorhabditis elegans genome

James C. Whisstock, James A. Irving, Stephen P. Bottomley, Robert N. Pike, Arthur M. Lesk

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1999

Language:

english

File:

PDF, 862 KB

english, 1999

11

The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly

Katherine Baran, Michelle Dunstone, Jenny Chia, Annette Ciccone, Kylie A. Browne, Christopher J.P. Clarke, Natalya Lukoyanova, Helen Saibil, James C. Whisstock, Ilia Voskoboinik, Joseph A. Trapani

Journal:

Year:

2009

Language:

english

File:

PDF, 1.38 MB

english, 2009

12

Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins

Wun-Shaing W. Chang, James Whisstock, Paul C.R. Hopkins, Arthur M. Lesk, Robin W. Carrell, Mark R. Wardell

Journal:

Protein Science

Year:

1997

Language:

english

File:

PDF, 7.43 MB

english, 1997

13

MUSTANG: A multiple structural alignment algorithm

Arun S. Konagurthu, James C. Whisstock, Peter J. Stuckey, Arthur M. Lesk

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2006

Language:

english

File:

PDF, 790 KB

english, 2006

14

Use of synthetic peptides to delineate discontinuous sequence regions involved in epitope sites of the thyrotropin β-subunit

Peter T. Gomme, Philip E. Thompson, James Whisstock, Peter G. Stanton, Milton T. W. Hearn

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1999

Language:

english

File:

PDF, 722 KB

english, 1999

15

Protection from Endogenous Perforin: Glycans and the C Terminus Regulate Exocytic Trafficking in Cytotoxic Lymphocytes

Amelia J. Brennan, Jenny Chia, Kylie A. Browne, Annette Ciccone, Sarah Ellis, Jamie A. Lopez, Olivia Susanto, Sandra Verschoor, Hideo Yagita, James C. Whisstock, Joseph A. Trapani, Ilia Voskoboinik

Journal:

Year:

2011

Language:

english

File:

PDF, 1.08 MB

english, 2011

16

Perforin: structure, function, and role in human immunopathology

Ilia Voskoboinik, Michelle A. Dunstone, Katherine Baran, James C. Whisstock, Joseph A. Trapani

Journal:

Immunological Reviews

Year:

2010

Language:

english

File:

PDF, 716 KB

english, 2010

17

Functional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence

Francis Alonzo III, Bobbi Xayarath, James C. Whisstock, Nancy E. Freitag

Journal:

Molecular Microbiology

Year:

2011

Language:

english

File:

PDF, 1.72 MB

english, 2011

18

The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria

Corrine J. Porter, Radhika Bantwal, Trudi L. Bannam, Carlos J. Rosado, Mary C. Pearce, Vicki Adams, Dena Lyras, James C. Whisstock, Julian I. Rood

Journal:

Molecular Microbiology

Year:

2012

Language:

english

File:

PDF, 3.78 MB

english, 2012

19

The MACPF/CDC family of pore-forming toxins

Carlos J. Rosado, Stephanie Kondos, Tara E. Bull, Michael J. Kuiper, Ruby H. P. Law, Ashley M. Buckle, Ilia Voskoboinik, Phillip I. Bird, Joseph A. Trapani, James C. Whisstock, Michelle A. Dunstone

Journal:

Cellular Microbiology

Year:

2008

Language:

english

File:

PDF, 367 KB

english, 2008

20

Serpins 2005 – fun between the β-sheets : Meeting report based upon presentations made at the 4th International Symposium on Serpin Structure, Function and Biology (Cairns, Australia)

James C. Whisstock, Stephen P. Bottomley, Phillip I. Bird, Robert N. Pike, Paul Coughlin

Journal:

Year:

2005

Language:

english

File:

PDF, 268 KB

english, 2005

21

Structural biology: Serpins' mystery solved

Whisstock, James C., Bottomley, Stephen P.

Journal:

Year:

2008

Language:

english

File:

PDF, 1.08 MB

english, 2008

22

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP

Paton, Adrienne W., Beddoe, Travis, Thorpe, Cheleste M., Whisstock, James C., Wilce, Matthew C. J., Rossjohn, Jamie, Talbot, Ursula M., Paton, James C.

Journal:

Year:

2006

Language:

english

File:

PDF, 309 KB

english, 2006

23

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I–bound peptide

Tynan, Fleur E, Burrows, Scott R, Buckle, Ashley M, Clements, Craig S, Borg, Natalie A, Miles, John J, Beddoe, Travis, Whisstock, James C, Wilce, Matthew C, Silins, Sharon L

Journal:

Nature Immunology

Year:

2005

Language:

english

File:

PDF, 584 KB

english, 2005

24

The matrix refolded

Buckle, Ashley M, Devlin, Glyn L, Jodun, Rachel A, Fulton, Kate F, Faux, Noel, Whisstock, James C, Bottomley, Stephen P

Journal:

Year:

2005

Language:

english

File:

PDF, 89 KB

english, 2005

25

Use of synthetic peptides to delineate discontinuous sequence regions involved in epitope sites of the thyrotropin β-subunit

Peter T. Gomme, Philip E. Thompson, James Whisstock, Peter G. Stanton, Milton T. W. Hearn

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1999

Language:

english

File:

PDF, 81 KB

english, 1999

26

Serpins: Finely Balanced Conformational Traps

Robert N. Pike, Stephen P. Bottomley, James A. Irving, Phillip I. Bird, James C. Whisstock

Journal:

Year:

2002

Language:

english

File:

PDF, 252 KB

english, 2002

27

For the record: A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica

Peter M. Smooker, James C. Whisstock, James A. Irving, Sugeeshwara Siyaguna, Terry W. Spithill, Robert N. Pike

Journal:

Protein Science

Year:

2000

Language:

english

File:

PDF, 1.90 MB

english, 2000

28

Cleaved antitrypsin polymers at atomic resolution

Michelle A. Dunstone, Jamie Rossjohn, Susanne C. Feil, Michael W. Parker, Weiwen Dai, James C. Whisstock, Robert N. Pike, Stephen P. Bottomley, Bernard F. Le Bonniec

Journal:

Protein Science

Year:

2000

Language:

english

File:

PDF, 2.28 MB

english, 2000

29

The role of strand 1 of the C β-sheet in the structure and function of α1-antitrypsin

Stephen P. Bottomley, Isobel D. Lawrenson, Deborah Tew, Weiwen Dai, James C. Whisstock, Robert N. Pike

Journal:

Protein Science

Year:

2001

Language:

english

File:

PDF, 271 KB

english, 2001

30

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2

Peter J.M. Steenbakkers, James A. Irving, Harry R. Harhangi, Willem J.C. Swinkels, Anna Akhmanova, Rembrandt Dijkerman, Mike S.M. Jetten, Chris van der Drift, James C. Whisstock, Huub J.M. Op den Camp

Journal:

Mycological Research

Year:

2008

Language:

english

File:

PDF, 428 KB

english, 2008

31

Molecular gymnastics: serpin structure, folding and misfolding

James C Whisstock, Stephen P Bottomley

Journal:

Current Opinion in Structural Biology

Year:

2006

Language:

english

File:

PDF, 791 KB

english, 2006

32

Structural insights into multi-protein communication systems

Christine Orengo, James Whisstock

Journal:

Current Opinion in Structural Biology

Year:

2012

Language:

english

File:

PDF, 159 KB

english, 2012

33

The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of an Inhibitor Family

Stephanie X. Wang, Kailash C. Pandey, Julio Scharfstein, James Whisstock, Rick K. Huang, Jordan Jacobelli, Robert J. Fletterick, Philip J. Rosenthal, Magnus Abrahamson, Linda S. Brinen, Andrea Rossi,

Journal:

Year:

2007

Language:

english

File:

PDF, 1.36 MB

english, 2007

34

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

Tina S. Skinner-Adams, Colin M. Stack, Katharine R. Trenholme, Chris L. Brown, Jolanta Grembecka, Jonathan Lowther, Artur Mucha, Marcin Drag, Pawel Kafarski, Sheena McGowan, James C. Whisstock, Donald

Journal:

Trends in Biochemical Sciences

Year:

2010

Language:

english

File:

PDF, 824 KB

english, 2010

35

An atlas of serpin conformations

James Whisstock, Richard Skinner, Arthur M. Lesk

Journal:

Trends in Biochemical Sciences

Year:

1998

Language:

english

File:

PDF, 2.89 MB

english, 1998

36

SH3 domains in prokaryotes

James C. Whisstock, Arthur M. Lesk

Journal:

Trends in Biochemical Sciences

Year:

1999

Language:

english

File:

PDF, 335 KB

english, 1999

37

The 1.5 Å Crystal Structure of a Prokaryote Serpin: Controlling Conformational Change in a Heated Environment

James A. Irving, Lisa D. Cabrita, Jamie Rossjohn, Robert N. Pike, Stephen P. Bottomley, James C. Whisstock

Journal:

Year:

2003

Language:

english

File:

PDF, 495 KB

english, 2003

38

Conservation within the myosin motor domain: implications for structure and function

M Jamie TV Cope, James Whisstock, Ivan Rayment, John Kendrick-Jones

Journal:

Year:

1996

Language:

english

File:

PDF, 3.10 MB

english, 1996

39

Evidence That Serpin Architecture Intrinsically Supports Papain-like Cysteine Protease Inhibition: Engineering α1-Antitrypsin To Inhibit Cathepsin Proteases†

Irving, James A., Pike, Robert N., Dai, Weiwen, Brömme, Dieter, Worrall, D. Margaret, Silverman, Gary A., Coetzer, Theresa H. T., Dennison, Clive, Bottomley, Stephen P., Whisstock, James C.

Journal:

Year:

2002

Language:

english

File:

PDF, 70 KB

english, 2002

40

α1-Antitrypsin Polymerisation Can Occur by both Loop A and C Sheet Mechanisms

Stephen P. Bottomley, Paul C.R. Hopkins, James C. Whisstock

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 174 KB

english, 1998

41

Expression and Purification of Recombinant Human Granzyme B from Pichia pastoris

Jiuru Sun, Catherina H. Bird, Marguerite S. Buzza, Katherine E. McKee, James C. Whisstock, Phillip I. Bird

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 174 KB

english, 1999

42

The 2.6 Å structure of antithrombin indicates a conformational change at the heparin binding site

Richard Skinner, Jan-Pieter Abrahams, James C Whisstock, Arthur M Lesk, Robin W Carrell, Mark R Wardell

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 3.18 MB

english, 1997

43

Conformational changes in serpins: I. the native and cleaved conformations of α1-antitrypsin

James C Whisstock, Richard Skinner, Robin W Carrell, Arthur M Lesk

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 1.09 MB

english, 2000

44

Conformational changes in serpins: I. the native and cleaved conformations of α1-antitrypsin

James C Whisstock, Richard Skinner, Robin W Carrell, Arthur M Lesk

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 1.27 MB

english, 2000

45

Conformational changes in serpins: II. the mechanism of activation of antithrombin by heparin

James C. Whisstock, Robert N. Pike, Lei Jin, Richard Skinner, Xue Y. Pei, Robin W. Carrell, Arthur M. Lesk

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 1.29 MB

english, 2000

46

Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3

Michelle K.M. Chow, Joel P. Mackay, James C. Whisstock, Martin J. Scanlon, Stephen P. Bottomley

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 625 KB

english, 2004

47

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death

Jamie A. Lopez, Amelia J. Brennan, James C. Whisstock, Ilia Voskoboinik, Joseph A. Trapani

Journal:

Trends in Immunology

Year:

2012

Language:

english

File:

PDF, 1.10 MB

english, 2012

48

The Crystal Structure of the Transthyretin-like Protein from Salmonella dublin, a Prokaryote 5-Hydroxyisourate Hydrolase

Sarah C. Hennebry, Ruby H.P. Law, Samantha J. Richardson, Ashley M. Buckle, James C. Whisstock

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 913 KB

english, 2006

49

Hijacking of a Substrate-binding Protein Scaffold for use in Mycobacterial Cell Wall Biosynthesis

Zara Marland, Travis Beddoe, Leyla Zaker-Tabrizi, Isabelle S. Lucet, Rajini Brammananth, James C. Whisstock, Matthew C.J. Wilce, Ross L. Coppel, Paul K. Crellin, Jamie Rossjohn

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 1.18 MB

english, 2006

50

The 1.6 Å Crystal Structure of the Catalytic Domain of PlyB, a Bacteriophage Lysin Active Against Bacillus anthracis

Corrine J. Porter, Raymond Schuch, Adam J. Pelzek, Ashley M. Buckle, Sheena McGowan, Matthew C.J. Wilce, Jamie Rossjohn, Ryann Russell, Daniel Nelson, Vincent A. Fischetti, James C. Whisstock

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.86 MB

english, 2007

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